Avicularin

Avicularin is a flavonoid glycoside that has been found in R. sachalinensis and has diverse biological activities. It inhibits fatty acid synthase (FASN) and aldose reductase (IC50s = 6.15 and 19.05 µM for the chicken liver and human enzymes, respectively). Avicularin scavenges DPPH and superoxide radicals, as well as inhibits copper-induced oxidation of LDL in cell-free assays (IC50s = 64.3, 6, and 3.8 µM, respectively). It inhibits LPS-induced increases in nitric oxide (NO) and prostaglandin E2 (PGE2, Cay-14010) production in RAW 264.7 macrophages when used at concentrations ranging from 30 to 300 µM. Avicularin (100 µg/ml) inhibits the proliferation, migration, and invasion of, as well as induces apoptosis and cell cycle arrest at the G0/G1 phase in, Huh7 hepatocellular carcinoma cells.Formal Name: 3-(alpha-L-arabinofuranosyloxy)-2-(3,4-dihydroxyphenyl)-5,7-dihydroxy-4H-1-benzopyran-4-one. CAS Number: 572-30-5. Synonyms: Quercetin 3-O-alpha-L-arabinofuranoside. Molecular Formula: C20H18O11. Formula Weight: 434.4. Purity: >98%. Formulation: (Request formulation change), A solid. Solubility: DMF: 50 mg/ml, DMSO: 30 mg/ml, Ethanol: 5 mg/ml, PBS (pH 7.2): insolu. lambdamax: 258, 359 nm. SMILES: O=C(C(O[C@@H]1O[C@@H](CO)[C@H](O)[C@H]1O)=C(C2=CC(O)=C(C=C2)O)OC3=CC(O)=C4)C3=C4O. InChi Code: InChI=1S/C20H18O11/c21-6-13-15(26)17(28)20(30-13)31-19-16(27)14-11(25)4-8(22)5-12(14)29-18(19)7-1-2-9(23)10(24)3-7/h1-5,13,15,17,20-26,28H,6H2/t13-,15-,17+,20-/m0/s1. InChi Key: BDCDNTVZSILEOY-UXYNSRGZSA-N. Origin: Synthetic.