Artemitin

Artemitin is a flavonoid that has been found in A. annua and has diverse biological activities. It scavenges peroxyl radicals in a cell-free assay in a concentration-dependent manner. Artemitin inhibits 5-lipoxygenase (5-LO) with an IC50 value of 54.6 µM. It is active against P. falciparum (IC50 = 26 µM). Artemitin is cytotoxic to HL-60 leukemia cells (IC50 = 30.98 µM). In vivo, artemitin (0.75 mg/kg) decreases mean arterial blood pressure in normotensive rats, as well as reduces angiotensin I-induced, but not angiotensin II-induced, increases in mean arterial blood pressure in rats.Formal Name: 2-(3,4-dimethoxyphenyl)-5-hydroxy-3,6,7-trimethoxy-4H-1-benzopyran-4-one. CAS Number: 479-90-3. Synonyms: Artemetin, Artemisetin. Molecular Formula: C20H20O8. Formula Weight: 388.4. Purity: >98%. Formulation: (Request formulation change), A solid. Solubility: DMSO: Soluble, Methanol: Soluble. SMILES: O=C1C(OC)=C(C2=CC=C(OC)C(OC)=C2)OC3=C1C(O)=C(OC)C(OC)=C3. InChi Code: InChI=1S/C20H20O8/c1-23-11-7-6-10(8-12(11)24-2)18-20(27-5)17(22)15-13(28-18)9-14(25-3)19(26-4)16(15)21/h6-9,21H,1-5H3. InChi Key: RIGYMJVFEJNCKD-UHFFFAOYSA-N. Origin: Synthetic.