Aristolochic Acid

Aristolochic acid is an alkaloid originally isolated from A. radix that inhibits inflammatory phospholipase A2 (PLA2) activity (IC50 = 40 µM in human neutrophils). It inhibits human synovial fluid PLA2-induced edema in a dose-dependent manner in vivo which positively correlates with in vitro inhibition of PLA2. Aristolochic acid inhibits hemolytic activity of PLA2s TFV PL-X, TFV PL-Ia, and TFV PL-Ib from T. flavoviridis venom (IC50s = 4.6, 4.0, and 3.9 µM, respectively) but enhances the edema-inducing activity of TFV PL-Ia and TFV PL-Ib. Aristolochic acid exposure is also associated with progressive interstitial fibrosing nephropathy and upper urinary tract urothelial carcinomas.Formal Name: 8-methoxy-6-nitro-phenanthro[3,4-d]-1,3-dioxole-5-carboxylic acid. CAS Number: 313-67-7. Synonyms: Aristolochic Acid A, Aristolochic Acid I, NSC 11926, NSC 50413, Tardolyt. Molecular Formula: C17H11NO7. Formula Weight: 341.3. Purity: >98%. Formulation: (Request formulation change), A crystalline solid. Solubility: DMSO: 25mg/mL, Ethanol: Soluble, Water: Slightly soluble. lambdamax: 224, 320, 388 nm. SMILES: COC1=C(C=C([N+]([O-])=O)C2=C3C4=C(OCO4)C=C2C(O)=O)C3=CC=C1. InChi Code: InChI=1S/C17H11NO7/c1-23-12-4-2-3-8-9(12)5-11(18(21)22)14-10(17(19)20)6-13-16(15(8)14)25-7-24-13/h2-6H,7H2,1H3,(H,19,20). InChi Key: BBFQZRXNYIEMAW-UHFFFAOYSA-N.