A1-28

A1-28 is a disulfide bond-containing ionizable cationic lipid. It has been used in the generation of lipid nanoparticles (LNPs) for the delivery of CRISPR complementary single-guide RNA (sgRNA) and Cas9 mRNA for genome editing in vitro.Formal Name: bis(2-(dodecyldisulfaneyl)ethyl) 3,3'-((4-methyl-11-oxo-12-oxa-15,16-dithia-4,8-diazaoctacosyl)azanediyl)dipropionate. Synonyms: AMAP-O16B. Molecular Formula: C58H115N3O6S6. Formula Weight: 1142.9. Purity: >95%. Formulation: (Request formulation change), A solution in methyl acetate. Solubility: Chloroform: Soluble, Ethanol: Soluble. SMILES: CCCCCCCCCCCCSSCCOC(CCNCCCN(C)CCCN(CCC(OCCSSCCCCCCCCCCCC)=O)CCC(OCCSSCCCCCCCCCCCC)=O)=O. InChi Code: InChI=1S/C58H115N3O6S6/c1-5-8-11-14-17-20-23-26-29-32-50-68-71-53-47-65-56(62)37-41-59-40-35-42-60(4)43-36-44-61(45-38-57(63)66-48-54-72-69-51-33-30-27-24-21-18-15-12-9-6-2)46-39-58(64)67-49-55-73-70-52-34-31-28-25-22-19-16-13-10-7-3/h59H,5-55H2,1-4H3. InChi Key: DDSMZEKGYXRVRD-UHFFFAOYSA-N.