9-cis Retinal

9-cis Retinal is a natural retinoid that is produced by oxidation of 9-cis retinol by cis-retinol dehydrogenase (cRDH). It binds to cellular retinol-binding protein-I (CRBP-I) and CRBP-II (Kds = 8 and 5 nM, respectively) and to cellular retinaldehyde-binding protein (CRALBP, Kd = 53.3 nM). In vitro, 9-cis retinal inhibits differentiation of RCJ C5.18 chondrogenic cells into cartilage (IC50 = 8 nM). In vivo, it rescues cone electroretinogram (ERG) responses in Irbp-/- mice, which lack interphotoreceptor retinoid-binding protein and have diminished cone responses, when administered at a dose of 0.375 mg.Formal Name: 9-cis-retinal. CAS Number: 514-85-2. Synonyms: 9-cis Retinaldehyde, 9-cis Vitamin A aldehyde. Molecular Formula: C20H28O. Formula Weight: 284.4. Purity: >98%. Formulation: (Request formulation change), A crystalline solid. Solubility: Chloroform: 10 mg/ml, DMF: 25 mg/ml, DMSO: 16 mg/ml, Ethanol: 25 mg/ml, Ethanol:PBS (pH 7.2)(1:2): 0.3 mg/ml. lambdamax: 373 nm. SMILES: CC1=C(/C=C/C(C)=C\C=C\C(C)=C\C([H])=O)C(C)(C)CCC1. InChi Code: InChI=1S/C20H28O/c1-16(8-6-9-17(2)13-15-21)11-12-19-18(3)10-7-14-20(19,4)5/h6,8-9,11-13,15H,7,10,14H2,1-5H3/b9-6+,12-11+,16-8-,17-13+. InChi Key: NCYCYZXNIZJOKI-MKOSUFFBSA-N.