8(S),15(S)-DiHETE

8(S),15(S)-DiHETE is formed when 15(S)-HETE is subjected to further oxidation by 15-LO. It causes eosinophil chemotaxis with an ED50 value of 1.5 µM but is not chemotactic for neutrophils. 8(S),15(S)-DiHETE antagonizes the hyperalgesic activity of 8(R),15(S)-DiHETE and LTB4 in the rat hind paw pain model.Formal Name: 8S,15S-dihydroxy-5Z,9E,11Z,13E-eicosatetraenoic acid. CAS Number: 80234-65-7. Molecular Formula: C20H32O4. Formula Weight: 336.5. Purity: >95%. Formulation: (Request formulation change), A solution in ethanol. Solubility: DMF: 50 mg/ml, DMSO: 50 mg/ml, Ethanol: 50 mg/ml, PBS pH 7.2: 1 mg/ml. lambdamax: 268 nm. SMILES: CCCCC[C@H](O)/C=C/C=C\C=C\[C@@H](O)C/C=C\CCCC(O)=O. InChi Code: InChI=1S/C20H32O4/c1-2-3-8-13-18(21)14-9-4-5-10-15-19(22)16-11-6-7-12-17-20(23)24/h4-6,9-11,14-15,18-19,21-22H,2-3,7-8,12-13,16-17H2,1H3,(H,23,24)/b5-4-,11-6-,14-9+,15-10+/t18-,19+/m0/s1. InChi Key: NNPWRKSGORGTIM-HCCKYKKOSA-N.