5(S)-HEPE

5(S)-HEPE is an active metabolite of eicosapentaenoic acid (EPA, Cay-90110, Cay-90110.1, Cay-21908). It is formed from EPA by 5-lipoxygenase (5-LO). 5(S)-HEPE is an agonist of G protein-coupled receptor 119 (GPR119). It increases cAMP accumulation in CHO-K1 cells expressing human GPR119 when used at a concentration of 10 µM. 5(S)-HEPE increases glucose-induced insulin secretion from MING6 insulinoma pancreatic islets and glucagon-like peptide 1 (GLP-1) secretion from HuTu 80 adenocarcinoma cells when used at a concentration of 10 µM. Serum levels of 5(S)-HEPE are elevated in patients with hyperlipidemia.Formal Name: 5S-hydroxy-6E,8Z,11Z,14Z,17Z-eicosapentaenoic acid. CAS Number: 92008-51-0. Molecular Formula: C20H30O3. Formula Weight: 318.5. Purity: >98%. Formulation: (Request formulation change), A solution in ethanol. Solubility: 0.1 M Na2CO3: 2 mg/ml, DMF: Miscible, DMSO: Miscible, Ethanol: Miscible, PBS pH 7.2: 0.8 mg/ml. lambdamax: 236 nm. SMILES: CC/C=C\C/C=C\C/C=C\C/C=C\C=C/[C@@H](O)CCCC(=O)O. InChi Code: InChI=1S/C20H30O3/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-16-19(21)17-15-18-20(22)23/h3-4,6-7,9-10,12-14,16,19,21H,2,5,8,11,15,17-18H2,1H3,(H,22,23)/b4-3-,7-6-,10-9-,13-12-,16-14+/t19-/m1/s1. InChi Key: FTAGQROYQYQRHF-GHWNLOBHSA-N.