5,7,3',4'-Tetramethoxyflavone

5,7,3',4'-Tetramethoxyflavone
Artikelnummer Größe Datenblatt Manual SDB Lieferzeit Menge Preis
Cay40272-25 25 mg -

6 - 10 Werktage*

48,00 €
Cay40272-50 50 mg -

6 - 10 Werktage*

92,00 €
Cay40272-100 100 mg -

6 - 10 Werktage*

163,00 €
Cay40272-250 250 mg -

6 - 10 Werktage*

383,00 €
 
5,7,3',4'-Tetramethoxyflavone is a flavone that has been found in M. paniculata and has diverse... mehr
Produktinformationen "5,7,3',4'-Tetramethoxyflavone"
5,7,3',4'-Tetramethoxyflavone is a flavone that has been found in M. paniculata and has diverse biological activities. It selectively inhibits multidrug resistance-associated protein 1 (MRP1) over MRP2 (IC50s = 7.9 and >50 µM, respectively). 5,7,3',4'-Tetramethoxyflavone (0.03-30 µM) inhibits LPS-induced nitric oxide (NO) release in primary mouse peritoneal macrophages. It is active against P. falciparum (IC50 = 4.06 µg/ml). 5,7,3',4'-Tetramethoxyflavone (20 µM) is cytotoxic to B16/F10 melanoma cells. It inhibits IL-33-induced production of chemokine (C-C motif) ligand 2 (CCL2) and CCL5 in primary human mast cells when used at concentrations of 50 and 100 µM. In vivo, 5,7,3',4'-tetramethoxyflavone (100 mg/kg) decreases the synovial fluid levels of prostaglandin E2 (PGE2, Cay-14010), IL-1beta, and TNF-alpha in a rat model of surgically induced osteoarthritis.Formal Name: 2-(3,4-dimethoxyphenyl)-5,7-dimethoxy-4H-1-benzopyran-4-one. CAS Number: 855-97-0. Synonyms: 5,7,3',4'-tetramethyl Luteolin ether, Methoxyluteolin, Tetramethyl camphoral. Molecular Formula: C19H18O6. Formula Weight: 342.3. Purity: >98%. Formulation: (Request formulation change), A solid. Solubility: DMSO: Soluble, Methanol: Soluble. SMILES: O=C1C=C(C2=CC(OC)=C(OC)C=C2)OC3=CC(OC)=CC(OC)=C13. InChi Code: InChI=1S/C19H18O6/c1-21-12-8-17(24-4)19-13(20)10-15(25-18(19)9-12)11-5-6-14(22-2)16(7-11)23-3/h5-10H,1-4H3. InChi Key: CLXVBVLQKLQNRQ-UHFFFAOYSA-N. Origin: Synthetic.
Schlagworte: 5,7,3',4'-tetramethyl Luteolin ether, Methoxyluteolin, Tetramethyl camphoral, 2-(3,4-dimethoxyphenyl)-5,7-dimethoxy-4H-1-benzopyran-4-one
Hersteller: Cayman Chemical
Hersteller-Nr: 40272

Eigenschaften

Anwendung: Bioactive flavone
MW: 342.3 D
Formel: C19H18O6
Reinheit: >98%
Format: Solid

Datenbank Information

CAS : 855-97-0| Passende Produkte

Handhabung & Sicherheit

Lagerung: -20°C
Versand: +20°C (International: -20°C)
Achtung
Nur für Forschungszwecke und Laboruntersuchungen: Nicht für die Anwendung im oder am Menschen!
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