(±)5(6)-DiHET

5(6)-DiHET is a fully racemic version of the enantiomeric forms biosynthesized from 5(6)-EET (Cay-50211, Cay-10007260) by epoxide hydrolases. 5(6)-DiHET can be used to quantify 5(6)-EET due to the conversion of 5(6)-EET to 5(6)-delta-lactone in solution. 5(6)-DiHET activates large-conductance calcium-activated potassium (KCa1.1/BK) channels in smooth muscle cells from rat small coronary arteries. It is a substrate for sheep seminal vesicle COX, producing 5,6-dihydroxy prostaglandin E1 and F1alpha metabolites in vitro. 5(6)-DiHET levels decrease in plasma in a high-fat diet-induced rat model of hyperlipidemia.Formal Name: (±)5,6-dihydroxy-8Z,11Z,14Z-eicosatrienoic acid. CAS Number: 213382-49-1. Synonyms: (±)5,6-DiHETrE. Molecular Formula: C20H34O4. Formula Weight: 338.5. Purity: >95%. Formulation: (Request formulation change), A solution in ethanol. Solubility: DMF: 50 mg/ml, DMSO: 50 mg/ml, Ethanol: 50 mg/ml, PBS pH 7.2: 1 mg/ml. SMILES: CCCCC/C=C\C/C=C\C/C=C\C[C@@H](O)[C@H](O)CCCC(O)=O. InChi Code: InChI=1S/C20H34O4/c1-2-3-4-5-6-7-8-9-10-11-12-13-15-18(21)19(22)16-14-17-20(23)24/h6-7,9-10,12-13,18-19,21-22H,2-5,8,11,14-17H2,1H3,(H,23,24)/b7-6-,10-9-,13-12-/t18-,19-/m1/s1. InChi Key: GFNYAPAJUNPMGH-GMKBZGQBSA-N.