4'-O-Methylhonokiol

4'-O-Methylhonokiol is a phenol that has been found in M. grandiflora and has diverse biological activities. It is active against the bacteria B. subtilis, S. aureus, and M. smegmatis (MIC = 2.5 µg/ml for all) and the fungus T. mentagrophytes (MIC = 1.25 µg/ml). 4'-O-Methylhonokiol (10 and 30 µM) inhibits LPS-induced activation of NF-kB and production of nitric oxide (NO) in RAW 264.7 macrophages. In vivo, 4'-O-Methylhonokiol (20 and 200 mg/kg) reduces carrageenan-induced paw edema in mice. It reduces neuronal apoptosis and escape latency in the Morris water maze in a mouse model of Alzheimer's disease induced by amyloid-beta 1-42 (Abeta42) when administered at a dose of 1 mg/kg. 4-O-methylhonokiol also reduces plasma cholesterol and triglyceride levels, ameliorates hepatic steatosis, and improves insulin resistance in a mouse model of high-fat diet-induced obesity.Formal Name: 4'-methoxy-3',5-di-2-propen-1-yl-[1,1'-biphenyl]-2-ol. CAS Number: 68592-15-4. Synonyms: 4-Methoxyhonokiol, NSC 293101. Molecular Formula: C19H20O2. Formula Weight: 280.4. Purity: >95%. Formulation: (Request formulation change), A solution in Ethanol. Solubility: DMF: 33 mg/ml, DMSO: 33 mg/ml, Ethanol: 33 mg/ml, Ethanol:PBS (pH 7.2) (1:2): 0.3 mg/ml. SMILES: C=CCC1=CC(C2=CC(CC=C)=C(OC)C=C2)=C(O)C=C1. InChi Code: InChI=1S/C19H20O2/c1-4-6-14-8-10-18(20)17(12-14)15-9-11-19(21-3)16(13-15)7-5-2/h4-5,8-13,20H,1-2,6-7H2,3H3. InChi Key: OQFHJKZVOALSPV-UHFFFAOYSA-N. Origin: Plant/Magnolia officinalis.