3beta-hydroxy-5-Cholestenoic Acid

3beta-hydroxy-5-Cholestenoic acid is an active metabolite of cholesterol formed when cholesterol is metabolized by the cytochrome P450 (CYP) isomer CYP27A1. 3beta-hydroxy-5-Cholestenoic acid is a modulator of gamma-secretase that decreases amyloid beta (1-42) peptide (Abeta42, EC50 = 250 nM) and increases Abeta38 levels with no effect on total Abeta in CHO2B7 cells. It decreases endogenous murine Abeta42 production by 60 and 75% in mouse postnatal neuron-glia cultures at concentrations of 3 and 10 µM, respectively.Formal Name: (3beta)-3-hydroxy-cholest-5-en-26-oic acid. CAS Number: 6561-58-6. Synonyms: 3beta-hydroxy-5-CA, Cholesterol-26-carboxylic Acid. Molecular Formula: C27H44O3. Formula Weight: 416.6. Purity: >95%. Formulation: (Request formulation change), A solid. Solubility: DMSO: Soluble. SMILES: [H][C@]12[C@@]([C@@](CC[C@]3([H])[C@H](C)CCCC(C)C(O)=O)([H])[C@]3(C)CC2)([H])CC=C4C[C@@H](O)CC[C@@]41C. InChi Code: InChI=1S/C27H44O3/c1-17(6-5-7-18(2)25(29)30)22-10-11-23-21-9-8-19-16-20(28)12-14-26(19,3)24(21)13-15-27(22,23)4/h8,17-18,20-24,28H,5-7,9-16H2,1-4H3,(H,29,30)/t17-,18?,20+,21+,22-,23+,24+,26+,27-/m1/s1. InChi Key: WVXOMPRLWLXFAP-AMQKJUDNSA-N.