20(S)-Protopanaxatriol

20(S)-Protopanaxatriol is an active aglycone metabolite of various panaxatriol ginsenosides, including ginsenoside Re (Cay-15330), ginsenoside Rf (Cay-23667), ginsenoside Rg1 (Cay-15315), ginsenoside Rg2 (Cay-15331), and ginsenoside Rh1 (Cay-27318). It is cytotoxic to HL-60 cancer cells (IC50 = 16 µM). 20(S)-Protopanaxatriol inhibits the proliferation of human umbilical vein endothelial cells (HUVECs, EC50 = 6.64 µg/ml). It inhibits LPS-induced increases in the protein levels of COX-2 and inducible nitric oxide synthase (iNOS) and decreases LPS-induced NF-kappaB activity in RAW 264.7 cells when used at concentrations ranging from 1 to 20 µM.Formal Name: (3beta,6alpha,12beta)-dammar-24-ene-3,6,12,20-tetrol. CAS Number: 34080-08-5. Synonyms: 20(S)-APPT, 20(S)-PPT. Molecular Formula: C30H52O4. Formula Weight: 476.7. Purity: >95%. Formulation: (Request formulation change), A crystalline solid. Solubility: DMF: 30 mg/ml, DMSO: 30 mg/ml, Ethanol: 30 mg/ml, Ethanol:PBS (pH 7.2) (1:3): 0.25 mg/ml. SMILES: CC1(C)[C@@H](O)CC[C@@]2(C)[C@@]1([H])[C@@H](O)C[C@]3(C)[C@]2([H])C[C@@H](O)[C@@]4([H])[C@@]3(C)CC[C@]4([H])[C@@](C)(O)CC/C=C(C)/C. InChi Code: InChI=1S/C30H52O4/c1-18(2)10-9-13-30(8,34)19-11-15-28(6)24(19)20(31)16-22-27(5)14-12-23(33)26(3,4)25(27)21(32)17-29(22,28)7/h10,19-25,31-34H,9,11-17H2,1-8H3/t19-,20+,21-,22+,23-,24-,25-,27+,28+,29+,30-/m0/s1. InChi Key: SHCBCKBYTHZQGZ-CJPZEJHVSA-N. Origin: Plant/Ginseng Radix et Rhizoma.