2-methoxy Estrone

2-methoxy Estrone is an active metabolite of the endogenous estrogen estrone (Cay-10006485). It is formed from estrone by catechol-O-methyltransferase (COMT). 2-methoxy Estrone inhibits the proliferation of isolated bovine brain-derived capillary endothelial cells (IC50 = 11.5 µM). It increases the levels of 6-keto prostaglandin F1alpha (6-keto PGF1alpha, Cay-15210) in human umbilical vein endothelial cells (HUVECs) when used at concentrations of 0.001, 0.01, and 0.1 µM. 2-methoxy Estrone (0.5 mg/kg) reduces ovariectomy-induced increases in serum cholesterol in rats.Formal Name: 3-hydroxy-2-methoxy-estra-1,3,5(10)-trien-17-one. CAS Number: 362-08-3. Synonyms: 2-MeOE1, 2-methoxy E1. Molecular Formula: C19H24O3. Formula Weight: 300.4. Purity: >95%. Formulation: (Request formulation change), A solid. Solubility: Chloroform: slightly soluble. InChi Code: InChI=1S/C19H24O3/c1-19-8-7-12-13(15(19)5-6-18(19)21)4-3-11-9-16(20)17(22-2)10-14(11)12/h9-10,12-13,15,20H,3-8H2,1-2H3/t12-,13+,15-,19-/m0/s1. InChi Key: WHEUWNKSCXYKBU-QPWUGHHJSA-N.