17alpha-hydroxy Pregnenolone

17alpha-hydroxy Pregnenolone is a metabolite of pregnenolone (Cay-19864) and a precursor in the biosynthesis of dehydroepiandrosterone (DHEA, Cay-15728). It is formed from pregnenolone by cytochrome P450 (CYP) isoform CYP17A1 hydroxylase activity and then converted to dehydroepiandrosterone by CYP17A1-mediated 17,20-lyase activity. Plasma levels of 17alpha-hydroxy pregnenolone are elevated in patients with type II 3beta-hydroxysteroid dehydrogenase deficiency, a form of congenital adrenal hyperplasia.Formal Name: 3beta,17-dihydroxy-pregn-5-en-20-one. CAS Number: 387-79-1. Synonyms: NSC 63853, 17-alpha-OH Pregnenolone. Molecular Formula: C21H32O3. Formula Weight: 332.5. Purity: >95%. Formulation: (Request formulation change), A solid. Solubility: DMF: 0.5mg/mL, DMF:PBS (7.2) (1:1.5): 0.4mg/mL. SMILES: O[C@H](C1)CC[C@@]2(C)C1=CC[C@]3([H])[C@]2([H])CC[C@@]4(C)[C@@]3([H])CC[C@]4(O)C(C)=O. InChi Code: InChI=1S/C21H32O3/c1-13(22)21(24)11-8-18-16-5-4-14-12-15(23)6-9-19(14,2)17(16)7-10-20(18,21)3/h4,15-18,23-24H,5-12H2,1-3H3/t15-,16+,17-,18-,19-,20-,21-/m0/s1. InChi Key: JERGUCIJOXJXHF-TVWVXWENSA-N.