17-phenyl trinor Prostaglandin F2alpha-d4

17-phenyl trinor Prostaglandin F2alpha-d4 (17-phenyl trinor PGF2alpha-d4) contains four deuterium atoms at the 3, 3', 4, and 4' positions. It is intended for use as an internal standard for the quantification of 17-phenyl trinor PGF2alpha by GC- or LC-mass spectrometry. 17-phenyl trinor PGF2alpha is a metabolically stable analog of PGF2alpha and is a potent agonist for the FP receptor. It binds to the FP receptor on ovine luteal cells with a relative potency of 756% compared to that of PGF2alpha. At the rat recombinant FP receptor expressed in CHO cells 17-phenyl trinor PGF2alpha inhibits PGF2alpha binding with a Ki of 1.1 nM. The isopropyl ester of 17-phenyl trinor PGF2alpha-d4 is slightly better than PGF2alpha isopropyl ester in reducing the intraocular pressure in the cat eye without any irritation.Formal Name: 9alpha,11alpha,15S-trihydroxy-17-phenyl-18,19,20-trinor-prosta-5Z,13E-dien-1-oic-3,3,4,4-d4 acid. CAS Number: 58976-50-4. Synonyms: Bimatoprost (free acid)-d4, 17-phenyl trinor PGF2alpha-d4. Molecular Formula: C23H28D4O5. Formula Weight: 392.5. Purity: >99% deuterated forms (d1-d4). Formulation: (Request formulation change), A solution in methyl acetate. Solubility: DMF: 25 mg/ml, DMSO: 25 mg/ml, Ethanol: 30 mg/ml, PBS (pH 7.2): .5 mg/ml. SMILES: O[C@@H](CCC1=CC=CC=C1)/C=C/[C@H]2[C@H](O)C[C@H](O)[C@@H]2C/C=C\C([2H])([2H])C([2H])([2H])CC(O)=O. InChi Code: InChI=1S/C23H32O5/c24-18(13-12-17-8-4-3-5-9-17)14-15-20-19(21(25)16-22(20)26)10-6-1-2-7-11-23(27)28/h1,3-6,8-9,14-15,18-22,24-26H,2,7,10-13,16H2,(H,27,28)/b6-1-,15-14+/t18-,19+,20+,21-,22+/m0/s1/i2D2,7D2. InChi Key: YFHHIZGZVLHBQZ-QOHQNJFUSA-N.