(±)17(18)-EpETE

(±)17(18)-EpETE is biosynthesized by the stereospecific epoxidation of the omega-3 bond of EPA. (±)17(18)-EpETE at 100 nM was found to be a potent and selective activator of large-conductance calcium-activated potassium channels (KCa1.1/BK) in vascular smooth muscle cells. It is possible that some of the physiologic effects of fish oil-enhanced diets could be due to this epoxygenase metabolite.Formal Name: (±)17,18-epoxy-5Z,8Z,11Z,14Z-eicosatetraenoic acid. Synonyms: (±)17,18-EEQ, (±)17,18-epoxy Eicosatetraenoic Acid. Molecular Formula: C20H30O3. Formula Weight: 318.5. Purity: >90%. Formulation: (Request formulation change), A solution in ethanol. Solubility: DMF: 50 mg/ml, DMSO: 50 mg/ml, Ethanol: 50 mg/ml, PBS (pH 7.2): 1 mg/ml. SMILES: CC[C@@H]1[C@@H](O1)C/C=C\C/C=C\C/C=C\C/C=C\CCCC(O)=O. InChi Code: InChI=1S/C20H30O3/c1-2-18-19(23-18)16-14-12-10-8-6-4-3-5-7-9-11-13-15-17-20(21)22/h3,5-6,8-9,11-12,14,18-19H,2,4,7,10,13,15-17H2,1H3,(H,21,22)/b5-3-,8-6-,11-9-,14-12-/t18-,19+/m1/s1. InChi Key: GPQVVJQEBXAKBJ-YQLHGUCYSA-N.