(±)12-HETE

(±)12-HETE is a racemic mixture of the arachidonic acid metabolites 12(R)-HETE (Cay-34560) and 12(S)-HETE (Cay-34570). It is formed via non-enzymatic oxidation of arachidonic acid (Cay-90010, Cay-90010.1, Cay-10006607). 12(S)- and 12(R)-HETE are formed by 12S- and 12R-lipoxygenase-mediated oxidation of arachidonic acid, respectively. 12(R)-HETE can also be formed by oxidation of arachidonic acid mediated by cytochrome P450 (CYP450) enzymes. (±)12-HETE (1 µM) induces aggregation of isolated human neutrophils. Production of (±)12-HETE by platelets isolated from spontaneously hypertensive rats is increased compared with platelets isolated from normotensive rats.Formal Name: (±)12-hydroxy-5Z,8Z,10E,14Z-eicosatetraenoic acid. CAS Number: 71030-37-0. Synonyms: (±)-Hydroxyeicosatetraenoic Acid. Molecular Formula: C20H32O3. Formula Weight: 320.5. Purity: >95%. Formulation: (Request formulation change), A solution in ethanol. Solubility: 0.1 M Na2CO3: 2 mg/ml, DMF: Miscible, DMSO: Miscible, Ethanol: Miscible, PBS (pH 7.2): 0.8 mg/ml. lambdamax: 237 nm. SMILES: CCCCC/C=C\CC(O)/C=C/C=C\C/C=C\CCCC(O)=O. InChi Code: InChI=1S/C20H32O3/c1-2-3-4-5-10-13-16-19(21)17-14-11-8-6-7-9-12-15-18-20(22)23/h7-11,13-14,17,19,21H,2-6,12,15-16,18H2,1H3,(H,22,23)/b9-7-,11-8-,13-10-,17-14+. InChi Key: ZNHVWPKMFKADKW-VXBMJZGYSA-N.