(±)12(13)-EpOME-d4

(±)12(13)-EpOME-d4 is intended for use as an internal standard for the quantification of 12(13)-EpOME by GC- or LC-MS. 12(13)-EpOME is an epoxide formed primarily via metabolism of linoleic acid (Cay-90150, Cay-90150.1, Cay-21909) by the cytochrome P450 (CYP) isoforms CYP2J2, CYP2C8, and CYP2C9, however, CYP1A1 can contribute to 12(13)-EpOME production when pharmacologically induced. 12(S),13(R)-EpOME and 12(R),13(S)-EpOME are produced at equal proportions from linoleic acid by peroxygenase, whereas CYP450-mediated metabolism of linoleic acid exclusively produces 12(S),13(R)-EpOME, in E. lagascae microsomes.Formal Name: (±)12(13)epoxy-9Z-octadecenoic-9,10,12,13-d4 acid. Synonyms: (±)12,13-EODE-d4, Isoleukotoxin-d4, (±)-Vernolic Acid-d4. Molecular Formula: C18H28D4O3. Formula Weight: 300.5. Purity: >99% deuterated forms (d1-d4). Formulation: (Request formulation change), A solution in methyl acetate. Solubility: DMF: 50 mg/ml, DMSO: 50 mg/ml, Ethanol: 50 mg/ml, PBS (pH 7.2): 1 mg/ml. SMILES: CCCCC[C@]1([2H])[C@](O1)([2H])C/C([2H])=C([2H])\CCCCCCCC(O)=O. InChi Code: InChI=1S/C18H32O3/c1-2-3-10-13-16-17(21-16)14-11-8-6-4-5-7-9-12-15-18(19)20/h8,11,16-17H,2-7,9-10,12-15H2,1H3,(H,19,20)/b11-8-/t16-,17+/m1/s1/i8D,11D,16D,17D. InChi Key: CCPPLLJZDQAOHD-FIMKFYBQSA-N.