10-Shogaol

10-Shogaol is a phenol that has been found in Z. officinale and has diverse biological activities. It selectively inhibits COX-2 over COX-1 (IC50s = 7.5 and >50 µM, respectively). 10-Shogaol (100 and 200 µM) induces mortality in A. cantonensis larvae. It scavenges DPPH (Cay-14805) radicals in a cell-free assay when used at a concentration of 100 µM. 10-Shogal (2 µM) increases proliferation of isolated human keratinocytes and fibroblasts and migration of isolated human keratinocytes in a wound healing assay.Formal Name: 1-(4-hydroxy-3-methoxyphenyl)-4-tetradecen-3-one. CAS Number: 36752-54-2. Molecular Formula: C21H32O3. Formula Weight: 332.5. Purity: >98%. Formulation: (Request formulation change), A neat liquid. Solubility: Chloroform: soluble, Methanol: soluble. SMILES: O=C(CCC1=CC=C(C(OC)=C1)O)C=CCCCCCCCCC. InChi Code: InChI=1S/C21H32O3/c1-3-4-5-6-7-8-9-10-11-12-19(22)15-13-18-14-16-20(23)21(17-18)24-2/h11-12,14,16-17,23H,3-10,13,15H2,1-2H3. InChi Key: FADFGCOCHHNRHF-UHFFFAOYSA-N. Origin: Plant/Zingiber officinale.