10(S),17(S)-DiHDHA

10(S),17(S)-DiHDHA
Artikelnummer Größe Datenblatt Manual SDB Lieferzeit Menge Preis
Cay10008128-25 25 µg -

6 - 10 Werktage*

249,00 €
Cay10008128-50 50 µg -

6 - 10 Werktage*

443,00 €
Cay10008128-100 100 µg -

6 - 10 Werktage*

838,00 €
 
Protectin D1 (also known as neuroprotectin D1 when produced in neuronal tissues) is a DHA-derived... mehr
Produktinformationen "10(S),17(S)-DiHDHA"
Protectin D1 (also known as neuroprotectin D1 when produced in neuronal tissues) is a DHA-derived dihydroxy fatty acid that exhibits potent protective and anti-inflammatory activities. 10(S),17(S)-DiHDHA is a DHA metabolite, also referred to as protectin DX (PDX). It is produced by an apparent double lipoxygenase (LO)-mediated reaction in murine peritonitis exudates, in suspensions of human leukocytes, or by soybean 15-LO incubated with DHA. It differs from protectin D1 with respect to the stereochemistry of the C-10 hydroxyl and the double bond configuration at the 13 and 15 positions. 10(S),17(S)-DiHDHA blocks neutrophil infiltration in murine peritonitis by 20-25% at a dose of 1 ng/mouse. It also inhibits platelet activation by both impairing thromboxane (TX) synthesis and TX receptor activation.Formal Name: 10(S),17(S)-dihydroxy-4Z,7Z,11E,13Z,15E,19Z-docosahexaenoic acid. CAS Number: 871826-47-0. Synonyms: 10(S),17(S)-DiHDoHE, PDX, Protectin DX. Molecular Formula: C22H32O4. Formula Weight: 360.5. Purity: >98%. Formulation: (Request formulation change), A solution in ethanol. Solubility: 0.1 M Na2CO3: 1 mg/ml, DMF: Miscible, DMSO: Miscible, Ethanol: Miscible, PBS (pH 7.2): 0.5 mg/ml. lambdamax: 270 nm. SMILES: CC/C=C\C[C@H](O)/C=C/C=C\C=C\[C@@H](O)C/C=C\C/C=C\CCC(O)=O. InChi Code: InChI=1S/C22H32O4/c1-2-3-10-15-20(23)17-12-8-9-13-18-21(24)16-11-6-4-5-7-14-19-22(25)26/h3,5-13,17-18,20-21,23-24H,2,4,14-16,19H2,1H3,(H,25,26)/b7-5-,9-8-,10-3-,11-6-,17-12+,18-13+/t20-,21-/m0/s1. InChi Key: CRDZYJSQHCXHEG-XLBFCUQGSA-N.
Schlagworte: 10(S),17(S)-DiHDoHE, PDX, Protectin DX, 10(S),17(S)-dihydroxy-4Z,7Z,11E,13Z,15E,19Z-docosahexaenoic acid
Hersteller: Cayman Chemical
Hersteller-Nr: 10008128

Eigenschaften

Anwendung: Bioactive lipid assays
MW: 360.5 D
Formel: C22H32O4
Reinheit: >98%
Format: Solution

Datenbank Information

CAS : 871826-47-0| Passende Produkte

Handhabung & Sicherheit

Lagerung: -20°C
Versand: -20°C (International: -20°C)
Signalwort: Danger
GHS-Piktogramme:
H-Sätze: H225, H319, H333
P-Sätze: P210, P233, P240, P241, P242, P243, P264, P280, P304, P312, P303+P361+P353, P305+P351+P338, P337+P313, P370+P378, P403+P235, P501
Achtung
Nur für Forschungszwecke und Laboruntersuchungen: Nicht für die Anwendung im oder am Menschen!
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