1-hydroxy Vitamin D3

Vitamin D aids in the absorption of calcium and has central roles in bone formation and maintenance, hypertension, cancer, and immunity. 1-hydroxy Vitamin D3 is a synthetic prodrug which is converted by cytochrome P450 isoforms to the vitamin D receptor agonist 1,25-dihydroxy vitamin D3 in vivo. Such prodrugs are effective in suppressing the synthesis and secretion of parathyroid hormone in secondary hyperparathyroidism, an action which requires the vitamin D receptor. 1-hydroxy Vitamin D3 supports bone growth both in postmenopausal women and in glucocorticoid-induced osteoporosis. It also provides renal and cardiovascular protection during chronic kidney disease.Formal Name: 5-[2E-[(3aS)-1R-[1R,5-dimethylhexyl]octahydro-7aR-methyl-4H-inden-4-ylidene]ethylidene]-4-methylene-1R,3R-cyclohexanediol. CAS Number: 41294-56-8. Synonyms: Alfacalcidol, alpha-Calcidol, Etalpha, 1-hydroxy Cholecalciferol, Tevabone. Molecular Formula: C27H44O2. Formula Weight: 400.6. Purity: >95%. Formulation: (Request formulation change), A crystalline solid. Solubility: DMF: 20 mg/ml, DMSO: 20 mg/ml, Ethanol: 20 mg/ml, Ethanol:PBS (pH 7.2) (1:3): 0.30 mg/ml. lambdamax: 213, 265 nm. SMILES: C[C@@]12[C@](CC[C@]2([H])[C@H](C)CCCC(C)C)([H])/C(CCC1)=C/C=C3C[C@@H](O)C[C@H](O)C/3=C. InChi Code: InChI=1S/C27H44O2/c1-18(2)8-6-9-19(3)24-13-14-25-21(10-7-15-27(24,25)5)11-12-22-16-23(28)17-26(29)20(22)4/h11-12,18-19,23-26,28-29H,4,6-10,13-17H2,1-3,5H3/b21-11+,22-12-/t19-,23-,24-,25+,26+,27-/m1/s1. InChi Key: OFHCOWSQAMBJIW-AVJTYSNKSA-N.