1,24-dihydroxy Vitamin D3 (hydrate)

Vitamin D aids in the absorption of calcium and has central roles in bone formation and maintenance, hypertension, cancer, and immunity. In addition, the active form of vitamin D, 1,25-dihydroxy vitamin D3, decreases the proliferation and increases differentiation of keratinocytes. 1,24-dihydroxy Vitamin D3 is an analog of 1,25-dihydroxy vitamin D3 which, when used in a 4 µg/g ointment, safely and effectively suppresses psoriasis. It also is effective at increasing the time interval between phototherapy cycles when ultraviolet light is used for psoriasis. 1,24-dihydroxy Vitamin D3 inhibits the growth of both normal and psoriatic human keratinocytes (IC50 ~ 10 nM) via the vitamin D receptor. It also suppresses the production of RANTES and IL-8 by human dermal fibroblasts and reduces cutaneous lymphocyte-associated antigen on CD4+ T cells, impairing migration and skin infiltration.Formal Name: 4-methylene-5Z-[2E-[(3aS)-octahydro-1R-[4R-hydroxy-1R,5-dimethylhexyl]-7aR-methyl-4H-inden-4-ylidene]ethylidene]-1R,3S-cyclohexanediol, monohydrate. CAS Number: 93129-94-3. Synonyms: Bonalfa, Curatoderm, 1alpha,24(R)-Dihydroxycholecalciferol, PRI 2191, Tacalcitol, TV 02. Molecular Formula: C27H44O3 . H2O. Formula Weight: 434.7. Purity: >98%. Formulation: (Request formulation change), A crystalline solid. Solubility: DMF: 20 mg/ml, DMSO: 20 mg/ml, Ethanol: 20 mg/ml, Ethanol:PBS (pH 7.2) (1:3): 0.30 mg/ml. lambdamax: 212, 264 nm. SMILES: C[C@@]12[C@](CC[C@]2([H])[C@H](C)CC[C@@H](O)C(C)C)([H])/C(CCC1)=C/C=C3C[C@@H](O)C[C@H](O)C/3=C.O. InChi Code: InChI=1S/C27H44O3.H2O/c1-17(2)25(29)13-8-18(3)23-11-12-24-20(7-6-14-27(23,24)5)9-10-21-15-22(28)16-26(30)19(21)4,/h9-10,17-18,22-26,28-30H,4,6-8,11-16H2,1-3,5H3,1H2/b20-9+,21-10-,/t18-,22-,23-,24+,25-,26+,27-,/m1./s1. InChi Key: UCLYOJXQGOXQKJ-XXBHHXRKSA-N.