OG488 Diacetate Taxol Conjugate *Cell-Permeable*

OG488 Diacetate Taxol Conjugate is the same compound as Oregon GreenTM 488 Taxol, bis-acetate. Taxol, also known as Paclitaxel, is an anticancer agent. Taxol is known to promote tubulin assembly into stable aggregated structures. The OG488 Diacetate Taxol Conjugate is an effective fluorescent probe for studying microtubules in live cells. The diacetate blocking groups are readily cleaved in live cells by intracellular esterases to release the bright green OG488 fluorophore. The fluorescent label OG488 Diacetate is attached to paclitaxel by derivatization of the 7-beta-hydroxy group of native paclitaxel, minimizing the interference of OG488 fluorophore on the binding of the probe to microtubules. OG488 Diacetate Taxol Conjugate has been successfully used for live-cell tubulin labeling. It is much more cell-permeable than OG488 Taxol Conjugate (ABD-23175).