Ac-LEHD-AMC (trifluoroacetate salt)

Ac-LEHD-AMC is a fluorogenic substrate for caspase-9. Upon cleavage by caspase-9, 7-amino-4-methylcoumarin (AMC) is released and its fluorescence can be used to quantify caspase-9 activity. AMC displays excitation/emission maxima of 340-360/440-460 nm, respectively.Formal Name: N-acetyl-L-leucyl-L-alpha-glutamyl-L-histidyl-N-(4-methyl-2-oxo-2H-1-benzopyran-7-yl)-L-alpha-asparagine, trifluoroacetate salt. Synonyms: Ac-Leu-Glu-His-Asp-AMC, Caspase-9 Substrate. Molecular Formula: C33H41N7O11 . XCF3COOH. Formula Weight: 711.7. Purity: >95%. Formulation: (Request formulation change), A lyophilized powder. Solubility: Water: 1 mg/ml. SMILES: CC(C1=CC=C(C=C1O2)NC([C@@H](NC([C@H](CC3=CN=CN3)NC([C@@H](NC([C@H](CC(C)C)NC(C)=O)=O)CCC(O)=O)=O)=O)CC(O)=O)=O)=CC2=O.FC(F)(C(O)=O)F. InChi Code: InChI=1S/C33H41N7O11.C2HF3O2/c1-16(2)9-23(36-18(4)41)32(49)38-22(7-8-27(42)43)30(47)39-24(11-20-14-34-15-35-20)33(50)40-25(13-28(44)45)31(48)37-19-5-6-21-17(3)10-29(46)51-26(21)12-19,3-2(4,5)1(6)7/h5-6,10,12,14-16,22-25H,7-9,11,13H2,1-4H3,(H,34,35)(H,36,41)(H,37,48)(H,38,49)(H,39,47)(H,40,50)(H,42,43)(H,44,45),(H,6,7)/t22-,23-,24-,25-,/m0./s1. InChi Key: UOZNIAKIZDCQSH-NATPOTRJSA-N.