ZW4864 free base

Description: ZW4864 (free base) is an orally active and selective beta-catenin/B-Cell lymphoma 9 protein-protein interaction (beta-catenin/BCL9 PPI) inhibitor, with a K_i value of 0.76 µM and an IC_50 value of 0.87 µM [1]. ZW4864 (free base) also demonstrates good pharmacokinetic properties. Target: Wnt/beta-catenin. Smiles: CC(C)(Oc1cccc(c1)N1CCC[C@H](C1)C(=O)N(Cc1ccc(cc1)-c1cn[nH]c1)C1CC1)C(=O)N1CCNCC1. References: Wang Z, et al. Discovery of an Orally Bioavailable Small-Molecule Inhibitor for the beta-Catenin/B-Cell Lymphoma 9 Protein-Protein Interaction. J Med Chem. 2021,64(16):12109-12131.