ZL006

ZL006 is an inhibitor of the protein-protein interaction between neuronal nitric oxide synthase (nNOS) and postsynaptic density protein-95 (PSD-95). It inhibits NMDA-induced lactate dehydrogenase release (IC50 = 0.082 µM), as well as glutamate and glycine-induced, NMDA receptor-dependent production of nitric oxide (NO), in primary mouse neurons. ZL006 (1.5 mg/kg) prevents ischemia-induced increases in nNOS-PSD-95 complex formation in cortices isolated from a mouse model of ischemia-reperfusion injury induced by middle cerebral artery occlusion (MCAO). It reduces infarct size and increases survival in the same model. ZL006 suppresses mechanical and cold allodynia in a mouse model of neuropathic pain induced by paclitaxel (Cay-10461).Formal Name: 4-[[(3,5-dichloro-2-hydroxyphenyl)methyl]amino]-2-hydroxy-benzoic acid. CAS Number: 1181226-02-7. Molecular Formula: C14H11Cl2NO4. Formula Weight: 328.2. Purity: >98%. Formulation: (Request formulation change), A solid. Solubility: DMF: 30 mg/ml, DMSO: 30 mg/ml, DMSO:PBS (pH 7.2) (1:3): 0.25 mg/ml, Ethanol: 10 mg/ml. lambdamax: 310 nm. SMILES: O=C(C1=CC=C(NCC2=C(O)C(Cl)=CC(Cl)=C2)C=C1O)O. InChi Code: InChI=1S/C14H11Cl2NO4/c15-8-3-7(13(19)11(16)4-8)6-17-9-1-2-10(14(20)21)12(18)5-9/h1-5,17-19H,6H2,(H,20,21). InChi Key: RTEYSQSXRFVKTJ-UHFFFAOYSA-N.