Zapnometinib

Zapnometinib is a MEK inhibitor (IC50 = 5.73 nM) and an active metabolite of CI-1040 (Cay-11580). It reduces viral titers in A549 and MDCK cells infected with influenza A (EC50s = 6.356 and 4.498 µM, respectively). Zapnometinib (50 mg/kg per day) increases survival in H1N1pdm09 influenza A-infected mice.Formal Name: 2-[(2-chloro-4-iodophenyl)amino]-3,4-difluoro-benzoic acid. CAS Number: 303175-44-2. Synonyms: ATR-002, PD 0184264. Molecular Formula: C13H7ClF2INO2. Formula Weight: 409.6. Purity: >95%. Formulation: (Request formulation change), A solid. Solubility: DMSO: Soluble, Methanol: Soluble. lambdamax: 280, 325 nm. SMILES: O=C(C1=CC=C(C(F)=C1NC2=CC=C(C=C2Cl)I)F)O. InChi Code: InChI=1S/C13H7ClF2INO2/c14-8-5-6(17)1-4-10(8)18-12-7(13(19)20)2-3-9(15)11(12)16/h1-5,18H,(H,19,20). InChi Key: XCNBGWKQXRQKSA-UHFFFAOYSA-N.