Zanamivir-13C,15N2 (hydrate)

Zanamivir-13C,15N2 is intended for use as an internal standard for the quantification of zanamivir (Cay-15123) by GC- or LC-MS. Zanamivir is a sialic acid analog that inhibits neuraminidase release of newly replicated influenza virus particles. It has been shown to selectively inhibit the growth of influenza A and B viruses in plaque reduction assays with IC50 values ranging from 5 to 14 nM and to directly inhibit influenza A and B virus neuraminidases with IC50 values ranging from 0.6 to 7.9 nM in vitro. Intranasal zanamivir administration at 0.4 mg/kg twice daily reduces mortality and viral titers in lung homogenates of mice infected with influenza.Formal Name: 5-(acetylamino)-4-[(amino-15N-imino-15N-methyl-13C)amino]-2,6-anhydro-3,4,5-trideoxy-D-glycero-D-ido-non-2-enonic acid, hydrate. Molecular Formula: C11[13C]H20N2[15N]2O7 . XH2O. Formula Weight: 335.3. Purity: >98%. Formulation: (Request formulation change), A solid. Solubility: Water: slightly soluble. SMILES: OC(C1=C[C@H](N[13C]([15NH2])=[15NH])[C@@H](NC(C)=O)[C@@]([C@H](O)[C@H](O)CO)([H])O1)=O. InChi Code: InChI=1S/C12H20N4O7/c1-4(18)15-8-5(16-12(13)14)2-7(11(21)22)23-10(8)9(20)6(19)3-17/h2,5-6,8-10,17,19-20H,3H2,1H3,(H,15,18)(H,21,22)(H4,13,14,16)/t5-,6+,8+,9+,10+/m0/s1/i12+1,13+1,14+1. InChi Key: ARAIBEBZBOPLMB-ZFYKIEQESA-N.