Z-Prolyl-prolinal

Z-Prolyl-prolinal (ZPP) is an inhibitor of prolyl endopeptidase (Kis = 0.35 and 0.5 nM for the mouse and human enzymes, respectively). ZPP (4 and 40 µM) inhibits the formation of angiotensin (1-7) from angiotensin II in kidney sections isolated from wild-type and Ace2-/- mice. In vivo, ZPP (10 and 50 mg/kg) reduces hippocampal neuronal cell death in a rat model of global ischemia.Formal Name: (2S)-2-[[(2S)-2-formyl-1-pyrrolidinyl]carbonyl]-1-pyrrolidinecarboxylic acid, 1,1-dimethylethyl ester. CAS Number: 86925-97-5. Synonyms: Benzyloxycarbonyl-prolyl-prolinal, ZPP. Molecular Formula: C15H24N2O4. Formula Weight: 296.4. Purity: >98%. Formulation: (Request formulation change), A solid. Solubility: DMSO: Soluble: >10 mg/ml, Ethanol: Soluble: >10 mg/ml, PBS (pH 7.2): Sparingly soluble: 1-10 mg/ml. SMILES: CC(C)(C)OC(N1CCC[C@H]1C(N2CCC[C@H]2C=O)=O)=O. InChi Code: InChI=1S/C15H24N2O4/c1-15(2,3)21-14(20)17-9-5-7-12(17)13(19)16-8-4-6-11(16)10-18/h10-12H,4-9H2,1-3H3/t11-,12-/m0/s1. InChi Key: CTCMMWKUMNGTPE-RYUDHWBXSA-N.