YS-035 (hydrochloride)

YS-035 is a verapamil derivative that dose-dependently blocks calcium uptake via Na+/Ca2+ exchange in diverse types of cells (Ki = 28 µM). It inhibits calcium uptake by muscle cells, brain synaptosomes, and kidney fibroblasts. YS-035 also prevents calcium release from mitochondria induced by Ruthenium Red but not by uncouplers, respiratory inhibitors, or a chelating agent. YS-035 is used to characterize the role of calcium currents in smooth muscle and neuronal electrophysiology.Formal Name: N-[2-(3,4-dimethoxyphenyl)ethyl]-3,4-dimethoxy-N-methyl-benzeneethanamine, monohydrochloride. CAS Number: 89805-39-0. Molecular Formula: C21H29NO4 . HCl. Formula Weight: 395.9. Purity: >98%. Formulation: (Request formulation change), A crystalline solid. Solubility: DMF: 1 mg/ml, DMSO: 5 mg/ml, PBS (pH 7.2): 5 mg/ml. lambdamax: 230, 278 nm. SMILES: COC1=C(OC)C=CC(CCN(C)CCC2=CC(OC)=C(OC)C=C2)=C1.Cl. InChi Code: InChI=1S/C21H29NO4.ClH/c1-22(12-10-16-6-8-18(23-2)20(14-16)25-4)13-11-17-7-9-19(24-3)21(15-17)26-5,/h6-9,14-15H,10-13H2,1-5H3,1H. InChi Key: GYBONEHHSUABAO-UHFFFAOYSA-N.