WM-1119

WM-1119 is an orally bioavailable inhibitor of lysine acetyltransferase 6A (KAT6A/MOZ, IC50 = 6.3 nM). It binds to KAT6A with a Kd value of 2 nM and is selective for KAT6A over KAT5 and KAT7 (Kds = 2,200 and 500 nM, respectively), as well as over a panel of 159 additional targets at 1 and 10 µM. WM-1119 inhibits proliferation of EMRK1184 B cell lymphoma cells (IC50 = 0.25 µM). It reduces tumor growth and spleen weight in a murine EMRK1184 model when administered at a dose of 50 mg/kg four times per day.Formal Name: 3-fluoro-5-(2-pyridinyl)-benzoic acid, 2-[(2-fluorophenyl)sulfonyl]hydrazide. CAS Number: 2055397-28-7. Molecular Formula: C18H13F2N3O3S. Formula Weight: 389.4. Purity: >98%. Formulation: (Request formulation change), A crystalline solid. Solubility: DMF: 30 mg/ml, DMSO: 30 mg/ml, DMSO:PBS (pH 7.2) (1:4): 0.25 mg/ml. lambdamax: 223, 277 nm. SMILES: FC1=CC(C(NNS(C2=C(F)C=CC=C2)(=O)=O)=O)=CC(C3=NC=CC=C3)=C1. InChi Code: InChI=1S/C18H13F2N3O3S/c19-14-10-12(16-6-3-4-8-21-16)9-13(11-14)18(24)22-23-27(25,26)17-7-2-1-5-15(17)20/h1-11,23H,(H,22,24). InChi Key: QLXULUNLCRKWRD-UHFFFAOYSA-N.