WAY-316606

WAY-316606 is an inhibitor of secreted frizzled-related protein 1 (sFRP1, IC50 = 0.5 µM). It increases Wnt signaling in U2OS osteosarcoma cells (EC50 = 0.65 µM). WAY-316606 increases total bone area in a murine calvarial organ culture assay when used at concentrations greater than 0.1 nM.Formal Name: 5-(phenylsulfonyl)-N-4-piperidinyl-2-(trifluoromethyl)-benzenesulfonamide. CAS Number: 915759-45-4. Molecular Formula: C18H19F3N2O4S2. Formula Weight: 448.5. Purity: >98%. Formulation: (Request formulation change), A crystalline solid. Solubility: DMF: 3 mg/ml, DMSO: 3 mg/ml, DMSO:PBS (pH 7.2) (1:10): 0.1 mg/ml. lambdamax: 239 nm. SMILES: O=S(C1=CC=CC=C1)(C2=CC=C(C(F)(F)F)C(S(NC3CCNCC3)(=O)=O)=C2)=O. InChi Code: InChI=1S/C18H19F3N2O4S2/c19-18(20,21)16-7-6-15(28(24,25)14-4-2-1-3-5-14)12-17(16)29(26,27)23-13-8-10-22-11-9-13/h1-7,12-13,22-23H,8-11H2. InChi Key: ITBGJNVZJBVPLJ-UHFFFAOYSA-N.