W-5 (hydrochloride)

W-5 is a chlorine-deficient analog of W-7 (Cay-14826), a calmodulin antagonist that binds to calmodulin and inhibits Ca2+/calmodulin-regulated enzyme activities (Ki = 11 µM). W-5 is less active than its calmodulin antagonist counterpart, inhibiting CHO-K1, MCF-7 breast cancer, and human myeloid progenitor cell proliferation with IC50 values greater than 100 µM. As a weaker antagonist for calmodulin, W-5 is suitable for use as a control compound for understanding the specificity of other calmodulin antagonists.Formal Name: N-(6-aminohexyl)-1-naphthalenesulfonamide, monohydrochloride. CAS Number: 61714-25-8. Molecular Formula: C16H22N2O2S . HCl. Formula Weight: 342.9. Purity: >98%. Formulation: (Request formulation change), A crystalline solid. Solubility: DMF: 30 mg/ml, DMSO: 30 mg/ml, Ethanol: 0.33 mg/ml, PBS (pH 7.2): 10 mg/ml. lambdamax: 223, 289 nm. SMILES: O=S(C1=CC=CC2=CC=CC=C21)(NCCCCCCN)=O.Cl. InChi Code: InChI=1S/C16H22N2O2S.ClH/c17-12-5-1-2-6-13-18-21(19,20)16-11-7-9-14-8-3-4-10-15(14)16,/h3-4,7-11,18H,1-2,5-6,12-13,17H2,1H. InChi Key: HOCSVIGHWPLMFC-UHFFFAOYSA-N.