VX-509

VX-509 is a selective inhibitor of Janus kinase 3 (JAK3) with a Ki value of 2.5 nM in enzyme assays and an IC50 value of 50-170 nM in cellular assays dependent on JAK3 activity with no measurable activity against other JAK isotypes. At 10-100 mg/kg, it has been shown to dose dependently reduce proinflammatory responses in a rat collagen-induced arthritis model and a mouse model of oxazolone-induced delayed-type hypersensitivity.Formal Name: (2R)-2-methyl-2-[[2-(1H-pyrrolo[2,3-b]pyridin-3-yl)-4-pyrimidinyl]amino]-N-(2,2,2-trifluoroethyl)-butanamide. CAS Number: 944842-54-0. Synonyms: Decernotinib, VRT-831509. Molecular Formula: C18H19F3N6O. Formula Weight: 392.4. Purity: >98%. Formulation: (Request formulation change), A crystalline solid. Solubility: DMF: 25 mg/mL, DMF:PBS (pH 7.2)(1:3): 0.25 mg/mL, DMSO: 20 mg/mL, Ethanol: 12 mg/mL. lambdamax: 224, 262 nm. SMILES: CC[C@@](C(NCC(F)(F)F)=O)(C)NC1=NC(C2=CNC3=C2C=CC=N3)=NC=C1. InChi Code: InChI=1S/C18H19F3N6O/c1-3-17(2,16(28)25-10-18(19,20)21)27-13-6-8-23-15(26-13)12-9-24-14-11(12)5-4-7-22-14/h4-9H,3,10H2,1-2H3,(H,22,24)(H,25,28)(H,23,26,27)/t17-/m1/s1. InChi Key: ASUGUQWIHMTFJL-QGZVFWFLSA-N.