VO-OHpic (hydrate)

VO-OHpic is a specific inhibitor of phosphatase and tensin homolog (PTEN, IC50 = 35 nM in vitro). Through this action, it increases cellular phosphatidylinositol 3,4,5-trisphosphate (PIP3) levels, phosphorylation of Akt, and glucose uptake in adipocytes. In mice, VO-OHpic (10 µg/kg, i.p.) decreases left ventricular systolic pressure and heart rate and protects against ischemia/reperfusion-induced myocardial infarction. VO-OHpic also blocks the development of suppressor activity in regulatory T cells activated with indoleamine 2,3-dioxygenase.Formal Name: (OC-6-45)-aqua(3-hydroxy-2-pyridinecarboxylato-kappaN1,kappaO2)[3-(hydroxy-kappaO)-2-pyridinecarboxylato(2-)-kappaO2]oxo-vanadate(1-), hydrogen, trihydrate. CAS Number: 476310-60-8. Molecular Formula: C12H9N2O8V . H [3H2O]. Formula Weight: 415.2. Purity: >95%. Formulation: (Request formulation change), A crystalline solid. Solubility: PBS (pH 7.2): 1 mg/ml. lambdamax: 303 nm. SMILES: [OH2][V+2]([N]1=CC=CC(O)=C1C2=O)([O-]C3=CC=CN=C3C4=O)([O-]2)([O-]4)=O.O.O.O.[H+]. InChi Code: InChI=1S/2C6H5NO3.4H2O.O.V/c2*8-4-2-1-3-7-5(4)6(9)10,,,,,,/h2*1-3,8H,(H,9,10),4*1H2,,/q,,,,,,,+2/p-2. InChi Key: RFJZXRRNSIRYLW-UHFFFAOYSA-L.