VK3-OCH3

VK3-OCH3 is an analog of vitamin K3 (Cay-15950) that that has antiproliferative activities in vitro. It preferentially decreases proliferation of IMR-32, LA-N-1, NB-39, and SK-N-SH neuroblastoma cells (IC50s = 2.43, 1.55, 10.69, and 3.45 µM, respectively) compared with non-cancerous HUVEC and HDF cells (IC50s = 26.24 and 87.11 µM, respectively). It increases heme oxygenase-1 (HO-1) and caveolin-1 levels, induces apoptosis, and halts the cell cycle at the G2/M phase in IMR-32 cells. VK3-OCH3 also inhibits protein-tyrosine phosphorylase (PTPase) activity (IC50 = 57.2 µM in a cell-free assay), induces protein-tyrosine phosphorylation in Hep3B hepatoma cells when used at a concentration of 50 µM, and inhibits the growth of Hep3B cells (IC50 = 8.6 µM).Formal Name: 2-[(2-methoxyethyl)thio]-3-methyl-1,4-naphthalenedione. CAS Number: 255906-59-3. Synonyms: Vitamin K3-OCH3. Molecular Formula: C14H14O3S. Formula Weight: 262.3. Purity: >98%. Formulation: (Request formulation change), A crystalline solid. Solubility: DMF: 30 mg/ml, DMF:PBS(pH 7.2)(1:1): 0.5 mg/ml, DMSO: 25 mg/ml, Ethanol: 5 mg/ml. lambdamax: 257 nm. SMILES: O=C1C(SCCOC)=C(C)C(C2=CC=CC=C21)=O. InChi Code: InChI=1S/C14H14O3S/c1-9-12(15)10-5-3-4-6-11(10)13(16)14(9)18-8-7-17-2/h3-6H,7-8H2,1-2H3. InChi Key: JTCRCMIBIBLUOK-UHFFFAOYSA-N.