VHL Ligand 1 (hydrochloride)

VHL ligand 1 is a building block in the synthesis of proteolysis-targeting chimera technologies (PROTACs). It is the von Hippel-Lindau (VHL) E3 ligase binding portion of some VHL-based PROTACs, including BET PROTAC MZ1 (Cay-21622).Formal Name: (4R)-3-methyl-L-valyl-4-hydroxy-N-[[4-(4-methyl-5-thiazolyl)phenyl]methyl]-L-prolinamide, monohydrochloride. CAS Number: 1448189-80-7. Molecular Formula: C22H30N4O3S . HCl. Formula Weight: 467.0. Purity: >95%. Formulation: (Request formulation change), A crystalline solid. Solubility: DMF: 20 mg/ml, DMSO: 20 mg/ml, Ethanol: 20 mg/ml, PBS (pH 7.2): 10 mg/ml. lambdamax: 270 nm. SMILES: N[C@H](C(N1C[C@H](O)C[C@H]1C(NCC2=CC=C(C3=C(C)N=CS3)C=C2)=O)=O)C(C)(C)C.Cl. InChi Code: InChI=1S/C22H30N4O3S.ClH/c1-13-18(30-12-25-13)15-7-5-14(6-8-15)10-24-20(28)17-9-16(27)11-26(17)21(29)19(23)22(2,3)4,/h5-8,12,16-17,19,27H,9-11,23H2,1-4H3,(H,24,28),1H/t16-,17+,19-,/m1./s1. InChi Key: JYRTWGCWUBURGU-MSSRUXLCSA-N.