Verdinexor

Verdinexor is a reversible inhibitor of Exportin I (XPO1/CRM1) with anticancer and antiviral activities. It inhibits the growth of OCI-Ly3, OCI-Ly10, and CLBL1 diffuse large B cell lymphoma (DLBCL) cells (IC50s = 2.1, 41.8, and 8.5 nM, respectively). Verdinexor inhibits XPO1/CRM1-mediated nuclear transport of respiratory syncytial virus (RSV) M protein when used at concentrations greater than 1 µM. It reduces RSV A2 replication (IC50 = 0.96 µM) without affecting viability of A549 cells (CC50 = >38 µM). In vivo, verdinexor (20 mg/kg) reduces virus shedding, pulmonary TNF-alpha, IL-6, MCP-1, and IFN-gamma expression, and leukocyte infiltration into the bronchoalveolar space in a mouse model of influenza A viral infection. It also reduces viral burden in a ferret model of influenza A viral infection.Formal Name: (2Z)-3-[3-[3,5-bis(trifluoromethyl)phenyl]-1H-1,2,4-triazol-1-yl]-2-propenoic acid, 2-(2-pyridinyl)hydrazide. CAS Number: 1392136-43-4. Synonyms: KPT-335. Molecular Formula: C18H12F6N6O. Formula Weight: 442.3. Purity: >98%. Formulation: (Request formulation change), A crystalline solid. Solubility: DMSO: 88 mg/ml, Ethanol: 11 mg/ml. lambdamax: 232, 273 nm. SMILES: O=C(NNC1=CC=CC=N1)/C=C\N2C=NC(C3=CC(C(F)(F)F)=CC(C(F)(F)F)=C3)=N2. InChi Code: InChI=1S/C18H12F6N6O/c19-17(20,21)12-7-11(8-13(9-12)18(22,23)24)16-26-10-30(29-16)6-4-15(31)28-27-14-3-1-2-5-25-14/h1-10H,(H,25,27)(H,28,31)/b6-4-. InChi Key: OPAKEJZFFCECPN-XQRVVYSFSA-N.