Verapamil (hydrochloride)

Verapamil (hydrochloride)
Artikelnummer Größe Datenblatt Manual SDB Lieferzeit Menge Preis
Cay14288-1 1 g -

6 - 10 Werktage*

39,00 €
 
Verapamil is the prototypical blocker of L-type calcium channels that produces... mehr
Produktinformationen "Verapamil (hydrochloride)"
Verapamil is the prototypical blocker of L-type calcium channels that produces excitation-contraction uncoupling in cardiac muscle by preventing the slow-inward current of calcium ions. Verapamil can also block calcium fluxes in vascular smooth muscle. It has both peripheral and coronary vasodilator effects (IC50 = 0.38 µM in guinea pig aortic strip) and has been used to control hypertension, angina, cardiac arrhythmia, and vascular headaches. Verapamil has also been used in cell biology as an inhibitor of drug efflux pump proteins such as P-glycoprotein, which are often over-expressed in certain tumor cell lines.Formal Name: alpha-[3-[[2-(3,4-dimethoxyphenyl)ethyl]methylamino]propyl]-3,4-dimethoxy-alpha-(1-methylethyl)-benzeneacetonitrile, monohydrochloride. CAS Number: 152-11-4. Synonyms: NSC 272366, NSC 657799, (±)-Verapamil. Molecular Formula: C27H38N2O4 . HCl. Formula Weight: 491.1. Purity: >98%. Formulation: (Request formulation change), A crystalline solid. Solubility: DMF: 16.7 mg/ml, DMSO: 10 mg/ml, Ethanol: 10 mg/ml, PBS (pH 7.2): 0.25 mg/ml. lambdamax: 205, 231, 280 nm. SMILES: COC1=CC=C(C(C(C)C)(C#N)CCCN(C)CCC2=CC=C(OC)C(OC)=C2)C=C1OC.Cl. InChi Code: InChI=1S/C27H38N2O4.ClH/c1-20(2)27(19-28,22-10-12-24(31-5)26(18-22)33-7)14-8-15-29(3)16-13-21-9-11-23(30-4)25(17-21)32-6,/h9-12,17-18,20H,8,13-16H2,1-7H3,1H. InChi Key: DOQPXTMNIUCOSY-UHFFFAOYSA-N.
Schlagworte: NSC 272366, NSC 657799, alpha-[3-[[2-(3,4-dimethoxyphenyl)ethyl]methylamino]propyl]-3,4-dimethoxy-alpha-(1-methylethyl)-benzeneacetonitrile, monohydrochloride
Hersteller: Cayman Chemical
Hersteller-Nr: 14288

Eigenschaften

Anwendung: L-type Calcium channel blocker
MW: 491.1 D
Formel: C27H38N2O4 . HCl
Reinheit: >98%
Format: Crystalline Solid

Datenbank Information

CAS : 152-11-4| Passende Produkte
KEGG ID : K04850 | Passende Produkte

Handhabung & Sicherheit

Lagerung: -20°C
Versand: -20°C (International: -20°C)
Signalwort: Danger
GHS-Piktogramme:
H-Sätze: H300, H311, H330
P-Sätze: P260, P264, P270, P271, P280, P284, P301+310, P302+352, P304+340, P310, P312, P320, P321, P330, P361+364, P403+233, P405, P501
Achtung
Nur für Forschungszwecke und Laboruntersuchungen: Nicht für die Anwendung im oder am Menschen!
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