Varlitinib

Varlitinib is an inhibitor of EGFR and HER2 (IC50s = 7 and 2 nM, respectively). It inhibits cell proliferation (IC50s = In vivo, varlitinib (100 mg/kg) inhibits phosphorylation of EGFR and ERK and reduces tumor weight in an MDA-MB-468 mouse xenograft model.Formal Name: N4-[3-chloro-4-(2-thiazolylmethoxy)phenyl]-N6-[(4R)-4,5-dihydro-4-methyl-2-oxazolyl]-4,6-quinazolinediamine. CAS Number: 845272-21-1. Synonyms: ARRY-334543. Molecular Formula: C22H19ClN6O2S. Formula Weight: 466.9. Purity: >98%. Formulation: (Request formulation change), A solid. Solubility: DMF: 5 mg/ml, DMSO: 5 mg/ml, Ethanol: 0.5 mg/ml, PBS (pH 7.2): partially soluble. lambdamax: 244, 303, 356 nm. SMILES: ClC1=C(OCC2=NC=CS2)C=CC(NC3=NC=NC4=C3C=C(NC5=N[C@H](C)CO5)C=C4)=C1. InChi Code: InChI=1S/C22H19ClN6O2S/c1-13-10-31-22(27-13)29-14-2-4-18-16(8-14)21(26-12-25-18)28-15-3-5-19(17(23)9-15)30-11-20-24-6-7-32-20/h2-9,12-13H,10-11H2,1H3,(H,27,29)(H,25,26,28)/t13-/m1/s1. InChi Key: UWXSAYUXVSFDBQ-CYBMUJFWSA-N.