Vanoxonin

Vanoxonin is a bacterial metabolite that has been found in S. hirsuta. It forms a complex with vanadium, and the complex inhibits thymidylate synthetase with an IC50 value of 0.7 µg/ml. The vanoxonin-vanadium complex is cytotoxic to L1210 leukemia cells (MIC = 25 µg/ml) and increases survival in Ehrlich murine spontaneous adenocarcinoma and L1210 mouse tumor models.Formal Name: N-(2,3-dihydroxybenzoyl)-L-threonyl-N5-acetyl-N5-hydroxy-L-ornithine. CAS Number: 86933-99-5. Synonyms: Antibiotic MG 245CF2A. Molecular Formula: C18H25N3O9. Formula Weight: 427.4. Purity: >80%. Formulation: (Request formulation change), A solid. SMILES: CC(N(O)CCC[C@@H](C(O)=O)NC([C@H]([C@H](O)C)NC(C1=C(C(O)=CC=C1)O)=O)=O)=O. InChi Code: InChI=1S/C18H25N3O9/c1-9(22)14(20-16(26)11-5-3-7-13(24)15(11)25)17(27)19-12(18(28)29)6-4-8-21(30)10(2)23/h3,5,7,9,12,14,22,24-25,30H,4,6,8H2,1-2H3,(H,19,27)(H,20,26)(H,28,29)/t9-,12+,14+/m1/s1. InChi Key: KCWDMHXDGAWLOA-LQJRIPTKSA-N. Origin: Bacterium/Saccharopolyspora hirsuta MG245-CF2.