Valrocemide

Valrocemide is an anticonvulsant and a derivative of valproic acid (Cay-13033). In vivo, valrocemide protects against seizures induced by maximal electroshock (MES), pentylenetetrazole (PTZ, Cay-18682), picrotoxin (Cay-20771), or bicuculline (Cay-11727) in mice (ED50s = 151, 132, 275, and 248 mg/kg, respectively). It prevents sound-induced seizures in Frings audiogenic-sensitive mice (ED50 = 52 mg/kg) and MES-induced seizures in rats (ED50 = 73 mg/kg). Valrocemide also prevents seizures in corneally kindled rats (ED50 = 161 mg/kg).Formal Name: N-(2-amino-2-oxoethyl)-2-propyl-pentanamide. CAS Number: 92262-58-3. Synonyms: N-Valproyl glycinamide, TV1901, VGD. Molecular Formula: C10H20N2O2. Formula Weight: 200.3. Purity: >95%. Formulation: (Request formulation change), A solid. Solubility: DMF: 30mg/mL, DMSO: 30mg/mL, DMSO:PBS (pH 7.2) (1:4): 0.2mg/mL, Ethanol: 25mg/mL. SMILES: CCCC(CCC)C(NCC(N)=O)=O. InChi Code: InChI=1S/C10H20N2O2/c1-3-5-8(6-4-2)10(14)12-7-9(11)13/h8H,3-7H2,1-2H3,(H2,11,13)(H,12,14). InChi Key: RALGCAOVRLYSMA-UHFFFAOYSA-N.