Urolithin B

Description: Urolithin B is one of the gut microbial metabolites of ellagitannins and is found in diverse plant foods, including pomegranates, berries, walnuts, tropical fruits, and medicinal herbs. Urolithin B inhibits NF-kappaB activity by reducing the phosphorylation and degradation of IkappaBalpha, and suppresses the phosphorylation of JNK, ERK, and Akt, and enhances the phosphorylation of AMPK. Urolithin B is also a regulator of skeletal muscle mass. Urolithin B has anti-inflammatory and antioxidant effects. Target: NF-kappaB, Endogenous Metabolite, AMPK, JNK, Akt, ERK. Smiles: Oc1ccc2c(c1)oc(=O)c1ccccc21. References: Lee G, et al. Anti-inflammatory and antioxidant mechanisms of urolithin B in activated microglia. Phytomedicine. 2019 Mar 1,55:50-57.