Urolithin B

Urolithin B is a metabolite of the polyphenolic antioxidant ellagic acid (Cay-10569) that has diverse biological activities. It is formed from ellagic acid via several intermediates by gut microbiota. Urolithin B reduces the levels of advanced glycation end products (AGEs) in a cell-free assay in a concentration-dependent manner. It inhibits aromatase activity in human placental microsomes and aromatase-sensitive MCF-7 (MCF-7aro) human breast cancer cells when used at concentrations of 47 and 4.7 µM, respectively. Urolithin B (1.18-4.7 nM) inhibits testosterone-induced proliferation of MCF-7aro cells. It also inhibits LPS-induced increases in inducible nitric oxide synthase (iNOS), TNF-alpha, IL-6, IL-1beta, and COX-2, as well as increases levels of IL-10, in BV-2 microglia when used at concentrations of 50 and 100 µM.Formal Name: 3-hydroxy-6H-dibenzo[b,d]pyran-6-one. CAS Number: 1139-83-9. Synonyms: NSC 94726, 3-hydroxy Urolithin. Molecular Formula: C13H8O3. Formula Weight: 212.2. Purity: >98%. Formulation: (Request formulation change), A solid. Solubility: DMF: 30 mg/ml, DMSO: 30 mg/ml, Ethanol: 30 mg/ml. lambdamax: 231, 279, 304 nm. SMILES: O=C1OC2=C(C3=C1C=CC=C3)C=CC(O)=C2. InChi Code: InChI=1S/C13H8O3/c14-8-5-6-10-9-3-1-2-4-11(9)13(15)16-12(10)7-8/h1-7,14H. InChi Key: WXUQMTRHPNOXBV-UHFFFAOYSA-N. Origin: Synthetic.