UK 5099

UK 5099 is a potent inhibitor of the mitochondrial pyruvate carrier (MPC) that inhibits pyruvate-dependent oxygen consumption by rat heart mitochondria (IC50 = 50 nM). It decreases glucose flux to the TCA cycle and increases production of M6 citrate via glutaminolytic flux through malic enzymes without affecting ATP-linked or uncoupled oxygen consumption in C2C12 myotubes when used at a concentration of 10 mM. UK 5099 decreases ATP-linked and uncoupled oxygen consumption in C2C12 myotubes when used in combination with BPTES (Cay-19284) and/or etomoxir (Cay-11969).Formal Name: 2-cyano-3-(1-phenyl-1H-indol-3-yl)-2-propenoic acid. CAS Number: 56396-35-1. Molecular Formula: C18H12N2O2. Formula Weight: 288.3. Purity: >95%. Formulation: (Request formulation change), A crystalline solid. Solubility: DMF: 15 mg/ml, DMF:PBS(pH 7.2)(1:1): 0.5 mg/ml, DMSO: 5 mg/ml. lambdamax: 210, 250, 383 nm. SMILES: O=C(/C(C#N)=C/C(C1=C2C=CC=C1)=CN2C3=CC=CC=C3)O. InChi Code: InChI=1S/C18H12N2O2/c19-11-13(18(21)22)10-14-12-20(15-6-2-1-3-7-15)17-9-5-4-8-16(14)17/h1-10,12H,(H,21,22)/b13-10+. InChi Key: BIZNHCWFGNKBBZ-JLHYYAGUSA-N.