Ubiquitin Isopeptidase Inhibitor I

Ubiquitin isopeptidase inhibitor I induces caspase activation and apoptosis (IC50 = ~1.7 µM) through a Bcl-2-dependent and apoptosome-independent mitochondrial pathway that selectively inhibits ubiquitin isopeptidase activity (IC50 = ~30 µM). It has also been shown to induce necrosis in apoptosis-resistant DKO cells.Formal Name: tetrahydro-3,5-bis[(4-nitrophenyl)methylene]-4H-thiopyran-4-one, 1,1-dioxide. CAS Number: 108477-18-5. Synonyms: NSC 144303. Molecular Formula: C19H14N2O7S. Formula Weight: 414.4. Purity: >98%. Formulation: (Request formulation change), A crystalline solid. Solubility: DMF: 1 mg/ml, DMSO: 15 mg/ml, DMSO:PBS(pH 7.2) (1:3): 0.25 mg/ml. lambdamax: 319 nm. SMILES: O=C(/C(CS(C/1)(=O)=O)=C\C2=CC=C([N+]([O-])=O)C=C2)C1=C/C3=CC=C([N+]([O-])=O)C=C3. InChi Code: InChI=1S/C19H14N2O7S/c22-19-15(9-13-1-5-17(6-2-13)20(23)24)11-29(27,28)12-16(19)10-14-3-7-18(8-4-14)21(25)26/h1-10H,11-12H2/b15-9-,16-10-. InChi Key: SSAMIOWVUGBIJK-VULZFCBJSA-N.