U93631

Description: GABAA receptor antagonist that binds the picrotoxin site and stabilizes the inactive form of the channel via allosteric interaction. Accelerates the decay of GABA-induced Cl- currents with little effect on peak amplitude. Also inhibits 5-HT3A receptors via a similar mechanism. Target: GABA Receptor. Smiles: CC(C)(C)OC(=O)c1ncn-2c1C(C)(C)Nc1ccccc-21. References: Dillon,GH et al. Mol Pharmacol. 1993 Oct,44(4):860-5.