U-99194 (maleate)

U-99194 is a dopamine D3 receptor antagonist (Ki = 160 nM for the human receptor). It is selective for dopamine D3 receptors over the alpha1-adrenergic receptor (alpha1-AR, Ki = 8,913 nM for the rat receptor), M1 muscarinic acetylcholine receptor (mAChR), serotonin (5-HT) receptor subtype 5-HT1A, and dopamine D4 receptor (Kis = 2,090, 4,230, and >10,000 nM for the human receptors). U-99194 reverses hypothermia induced by the D3 receptor agonists (+)-7-OH-DPAT or (+)-PD 128907 (Cay-21235) in rats with half-maximal inhibitory dose (ID50) values of 19.1 and 12.9 mg/kg, respectively. It increases non-social exploration, social investigation, and the latency to attack in a mouse model of isolation-induced aggressiveness when administered at a dose of 40 mg/kg.Formal Name: 2,3-dihydro-5,6-dimethoxy-N,N-dipropyl-1H-inden-2-amine, 2Z-butenedioate. CAS Number: 234757-41-6. Synonyms: PNU-99194, U-99194A. Molecular Formula: C17H27NO2 . C4H4O4. Formula Weight: 393.5. Purity: >98%. Formulation: (Request formulation change), A solid. Solubility: DMSO: Soluble, Methanol: Soluble. SMILES: OC(/C=C\C(O)=O)=O.CCCN(C1CC2=CC(OC)=C(OC)C=C2C1)CCC. InChi Code: InChI=1S/C17H27NO2.C4H4O4/c1-5-7-18(8-6-2)15-9-13-11-16(19-3)17(20-4)12-14(13)10-15,5-3(6)1-2-4(7)8/h11-12,15H,5-10H2,1-4H3,1-2H,(H,5,6)(H,7,8)/b,2-1-. InChi Key: FSIQDESGRQTFNN-BTJKTKAUSA-N.