U-73122

U-73122
Artikelnummer Größe Datenblatt Manual SDB Lieferzeit Menge Preis
AG-CR1-3698-M001 1 mg -

3 - 9 Werktage*

22,00 €
AG-CR1-3698-M005 5 mg -

3 - 9 Werktage*

77,00 €
 
White to off-white solid. Soluble in methylene chloride or chloroform (10mg/ml). Slightly soluble... mehr
Produktinformationen "U-73122"
White to off-white solid. Soluble in methylene chloride or chloroform (10mg/ml). Slightly soluble in DMSO (2mg/ml), DMF (2mg/ml) or 100% ethanol (1mg/ml). Sparingly soluble in aqueous solutions. See also Solubility Note below. Chemical. CAS: 112648-68-7. Formula: C29H40N2O3. MW: 464.6. Gasdermin D N-terminal fragment (GSDMD-N)-induced pyroptosis inhibitor. Protects against GSDMD-N cytotoxicity in macrophages or against lethal infection in mice. Useful agent for inflammasome research. Potent cell permeable phospholipase C (PLC) , phospholipase A2 and 5-LO (5-lipoxygenase) inhibitor. Affects the phospholipases by inhibiting the hydrolysis of PPI (phosphatidylinositol) to IP3 (inositol triphosphate), which in turn leads to a drop in cytosolic Ca2+. Potent inhibitor of the SERCA pump in smooth muscle. Potently inhibits Ca2+-release from isolated smooth muscle cells independent of its effect on PLC. Inhibits agonist-induced platelet aggregation. Potently inhibits human polymorphonuclear neutrophil adhesion on biological surfaces and exhibits antinociceptive activity in vivo. Shown to inhibit agonist-induced down-regulation of muscarinic receptors in SK-N-SH neuroblastoma cells. Activates TRPM4 and inhibits TRPM3 channels. Potent human telomerase inhibitor.
Schlagworte: 1-[6-[[(17beta)-3-Methoxyestra-1,3,5(10)-trien-17-yl]amino]hexyl]-1H-pyrrole-2,5-dione
Hersteller: AdipoGen Life Sciences
Hersteller-Nr: AG-CR1-3698

Eigenschaften

MW: 464,6 D
Formel: C29H40N2O3
Reinheit: >95%
Format: Solid

Datenbank Information

CAS : 112648-68-7| Passende Produkte

Handhabung & Sicherheit

Lagerung: -20°C
Versand: +20°C (International: +20°C)
Signalwort: Warning
GHS-Piktogramme:
H-Sätze: H315, H319, H335
P-Sätze: P261, P280, P302+P352, P304+P340, P305+P351+P338, P405
Achtung
Nur für Forschungszwecke und Laboruntersuchungen: Nicht für die Anwendung im oder am Menschen!
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