U-0521

U-0521 is an inhibitor of catechol-O-methyltransferase (COMT, Ki = 7.8 µM for the rat liver enzyme) and tyrosine hydroxylase (IC50 = 1 µM for the rabbit adrenal enzyme). It enhances epinephrine-induced contractions of isolated rabbit atria when used at a concentration of 55 µM. U-0521 (41.5 µmol/kg) also enhances isoprenaline- or epinephrine-induced increases in blood glucose levels in pancreatectomized rats. It decreases blood pressure in spontaneously hypertensive, but not normotensive, rats when administered at a dose of 50 mg/kg.Formal Name: 1-(3,4-dihydroxyphenyl)-2-methyl-1-propanone. CAS Number: 5466-89-7. Synonyms: 3',4'-Dihydroxy-2-methylpropiophenone, NSC 27389. Molecular Formula: C10H12O3. Formula Weight: 180.2. Purity: >95%. Formulation: (Request formulation change), A solid. Solubility: DMF: 3 mg/ml, DMSO: 5 mg/ml. lambdamax: 231, 277, 308 nm. SMILES: O=C(C(C)C)C1=CC=C(C(O)=C1)O. InChi Code: InChI=1S/C10H12O3/c1-6(2)10(13)7-3-4-8(11)9(12)5-7/h3-6,11-12H,1-2H3. InChi Key: VDQLKIBLTMPAHI-UHFFFAOYSA-N.